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Mn(2+)-doped NaYF4:Yb/Er upconversion nanoparticle-based electrochemiluminescent aptasensor for bisphenol A
Xiaofei Guo1, Shijia Wu1, Nuo Duan1
1State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Analytical and Bioanalytical Chemistry
|March 24, 2016
Summary
A new aptasensor using upconversion nanoparticles (UCNPs) offers sensitive electrogenerated chemiluminescence (ECL) detection of bisphenol A (BPA). This method accurately quantifies BPA from 0.05 to 100 ng/mL, providing a novel platform for ECL analysis.
Area of Science:
- Analytical Chemistry
- Nanotechnology
- Biomedical Engineering
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical with potential health risks.
- Sensitive and accurate detection methods for BPA are crucial for environmental and health monitoring.
- Upconversion nanoparticles (UCNPs) offer unique optical properties for advanced sensing applications.
Purpose of the Study:
- To develop a novel aptasensor for the sensitive detection of bisphenol A (BPA).
- To utilize Mn(2+)-doped NaYF4:Yb/Er upconversion nanoparticles (UCNPs) for electrogenerated chemiluminescence (ECL) detection.
- To establish a new platform for ECL applications using UCNPs.
Main Methods:
- Fabrication of an ECL aptasensor by immobilizing BPA aptamers on a gold nanoparticle (AuNPs)-modified electrode.
- Conjugation of complementary DNA labeled with NaYF4:Yb,Er/Mn UCNPs to the aptasensor.
- Measurement of ECL signals changes induced by BPA-aptamer interactions.
Main Results:
- The aptasensor demonstrated sensitive detection of BPA within a concentration range of 0.05 to 100 ng/mL.
- A low detection limit of 0.037 ng/mL for BPA was achieved.
- A significant decrease in ECL signal intensity was observed upon BPA interaction.
Conclusions:
- The developed UCNP-based aptasensor provides a rapid and accurate method for BPA detection.
- This study highlights the potential of UCNPs as a promising material for ECL-based sensing platforms.
- The novel aptasensor offers a valuable tool for monitoring BPA in various samples.
