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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

333
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
333
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

256
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
256

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Related Experiment Video

Updated: Mar 23, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

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Hepatic Perfusion Therapy.

Rahul Rajeev1, T Clark Gamblin1, Kiran K Turaga1

  • 1Division of Surgical Oncology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.

The Surgical Clinics of North America
|March 29, 2016
PubMed
Summary
This summary is machine-generated.

Isolated hepatic perfusion delivers chemotherapy directly to liver tumors by isolating the liver

Keywords:
Colorectal cancerHepatic metastasesHepatocellular carcinomaIsolated hepatic perfusionMelanomaPercutaneous hepatic perfusionRegional therapies

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Area of Science:

  • Oncology
  • Hepatology
  • Vascular Surgery

Background:

  • Hepatic malignancies present unique treatment challenges due to liver vascularity.
  • Systemic chemotherapy often has limited efficacy and significant side effects for liver cancers.

Purpose of the Study:

  • To describe the technique and potential benefits of isolated hepatic perfusion for liver malignancies.
  • To highlight applications in metastatic and primary liver cancers.

Main Methods:

  • Vascular isolation of the liver.
  • Chemotherapy delivery via the hepatic artery.
  • Chemotherapy extraction from the retrohepatic vena cava.

Main Results:

  • Observed benefits in hepatic metastases from ocular melanoma and colorectal cancer.
  • Demonstrated potential in primary hepatocellular carcinoma treatment.

Conclusions:

  • Isolated hepatic perfusion leverages liver vascularity for targeted chemotherapy delivery.
  • Further research is exploring percutaneous and prophylactic approaches.