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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Discovery and Development of a Three-Component Oxidopyrylium [5 + 2] Cycloaddition

Michael P D'Erasmo1,2, Christine Meck1,2, Chad A Lewis3

  • 1Department of Chemistry, Brooklyn College, The City University of New York , Brooklyn, New York 11210, United States.

The Journal of Organic Chemistry
|March 29, 2016
PubMed
Summary

New oxidopyrylium cycloaddition reactions using ethanol-stabilized chloroform generate novel α-ethoxyenone bicyclic products. This optimized three-component process offers a convenient route to diverse oxabicyclo[3.2.1]octane structures and α-hydroxytropolones.

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