Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

10.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of the TOFPET2c ASIC in time-of-flight detection of x-rays for scatter rejection in medical imaging applications.

Physics in medicine and biology·2025
Same author

Initial results of the Hyperion II<sup></sup>PET insert for simultaneous PET-MRI applied to atherosclerotic plaque imaging in New-Zealand white rabbits.

Physics in medicine and biology·2024
Same author

Correction to: Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner.

EJNMMI physics·2020
Same author

Emerging methods in radiology.

Der Radiologe·2020
Same author

Practical issues and limitations of brain attenuation correction on a simultaneous PET-MR scanner.

EJNMMI physics·2020
Same author

Excited-state electronic structure of molecules using many-body Green's functions: Quasiparticles and electron-hole excitations with VOTCA-XTP.

The Journal of chemical physics·2020
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Mar 23, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.8K

FPGA-based RF interference reduction techniques for simultaneous PET-MRI.

P Gebhardt1, J Wehner, B Weissler

  • 1Division of Imaging Sciences and Biomedical Engineering, King's College London, London WC2R 2LS, UK. Department of Physics of Molecular Imaging Systems, Institute of Experimental Molecular Imaging, RWTH Aachen University, 52062 Aachen, Germany.

Physics in Medicine and Biology
|April 7, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method to reduce electromagnetic interference in simultaneous PET-MRI systems. By adjusting clock frequencies and phases of PET detectors, researchers improved signal-to-noise ratios without hardware changes, enhancing imaging quality.

More Related Videos

Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI
11:00

Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI

Published on: March 19, 2021

5.2K
Simultaneous fMRI and Electrophysiology in the Rodent Brain
08:22

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

14.1K

Related Experiment Videos

Last Updated: Mar 23, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.8K
Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI
11:00

Reliable Acquisition of Electroencephalography Data during Simultaneous Electroencephalography and Functional MRI

Published on: March 19, 2021

5.2K
Simultaneous fMRI and Electrophysiology in the Rodent Brain
08:22

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

14.1K

Area of Science:

  • Medical Imaging Physics
  • Biomedical Engineering
  • Radiological Sciences

Background:

  • Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) offer powerful in vivo disease monitoring but face challenges due to electromagnetic interference (EMI).
  • EMI between PET detectors and MRI subsystems degrades signal-to-noise ratio (SNR) for both modalities, leading to image artifacts and reduced diagnostic accuracy.
  • Existing solutions like RF shielding can introduce other issues, such as eddy currents and limited system integration.

Purpose of the Study:

  • To develop and demonstrate novel methods for reducing radio-frequency (RF) interference in combined PET-MRI systems.
  • To improve the intrinsic performance and SNR of both PET and MRI modalities during simultaneous operation.
  • To enhance flexibility and adaptability of interference reduction techniques without requiring hardware modifications.

Main Methods:

  • Implemented RF interference reduction by modifying clock frequencies and phase relations of digital silicon photo-multipliers (dSiPMs) within PET modules.
  • Utilized Field-Programmable Gate Array (FPGA) for real-time clock adjustments.
  • Validated methods through electromagnetic field simulations, magnetic field mapping, and MRI noise/SNR scans with an operational PET insert.

Main Results:

  • Demonstrated optimized RF field emission from PET detectors, leading to reduced coupling into the MRI RF coil and improved RF silence.
  • Achieved significant MRI SNR improvements and artifact reduction by altering PET detector clock parameters.
  • Confirmed that firmware-based adjustments (clock frequency and phase shifting) effectively mitigate EMI without hardware changes.

Conclusions:

  • Firmware-based clock modulation of PET detectors offers an effective and flexible approach to mitigate RF interference in simultaneous PET-MRI.
  • This method enhances the performance of PET-MRI systems by preserving SNR and reducing artifacts, crucial for accurate disease monitoring and drug development.
  • The adaptability of this technique allows for optimization across different MRI systems and RF coil configurations.