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Gastroesophageal Reflux Disease in Children with Interstitial Lung Disease

M A Dziekiewicz1, K Karolewska-Bochenek2, Ł Dembiński1

  • 1Department of Pediatric Gastroenterology and Nutrition, Warsaw Medical University, 63A Żwirki i Wigury St, 01-091, Warsaw, Poland.

Advances in Experimental Medicine and Biology
|April 13, 2016
PubMed

Insights

Gastroesophageal reflux disease (GERD) is common in children with interstitial lung disease, affecting half of those studied. Non-acid and proximal reflux episodes were frequent, suggesting MII-pH monitoring is ideal for diagnosis.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Medical Diagnostics

Background:

  • Gastroesophageal reflux disease (GERD) is prevalent in adults with interstitial lung disease (ILD).
  • Limited data exist on GERD prevalence and characteristics in pediatric ILD patients.
  • This study addresses the knowledge gap regarding GERD in children with ILD.

Purpose of the Study:

  • To prospectively assess the incidence of GERD in children with ILD.
  • To characterize the features of GERD in this pediatric population.
  • To evaluate the utility of MII-pH monitoring for GERD detection in pediatric ILD.

Main Methods:

  • Prospective study involving 18 pediatric patients with ILD.
  • Diagnosis of GERD based on 24-hour pH-impedance monitoring (MII-pH).
  • Classification of gastroesophageal reflux episodes (GERs) as acid, weakly acid, weakly alkaline, or proximal.

Main Results:

  • GERD was diagnosed in 50% (9/18) of the pediatric patients.
  • A total of 1000 GERs were detected, with a median of 53.5 per patient.
  • 58.5% of GERs were acidic, 40.7% weakly acidic, and 0.8% weakly alkaline.
  • Proximal GERs constituted 63.7% of all reflux episodes.
  • Patients with GERD showed significantly higher numbers of proximal and total GERs.

Conclusions:

  • The prevalence of GERD in children with ILD is high and should be considered irrespective of symptoms.
  • Non-acid and proximal GERs are common in this population.
  • MII-pH monitoring is a preferred method for detecting reflux episodes in pediatric ILD patients due to its ability to identify diverse GER types.

Keywords:
ChildrenGastroesophageal reflux diseaseInterstitial lung diseaseReflux episodespH-impedance monitoring

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