Fiber Optic Surface Plasmon Resonance-Based Biosensor Technique: Fabrication, Advancement, and Application

Area of Science:

• Biomedical Engineering
• Optoelectronics
• Chemical Sensing

Background:

• Surface plasmon resonance (SPR) biosensors are powerful label-free optical detection tools.
• Fiber optic integration enhances SPR biosensing for various chemical and biological species.

Purpose of the Study:

• To review fiber optic-based SPR biosensor configurations and probe designs.
• To discuss the sensing principles and applications of key biosensor types.
• To explore future prospects of this technology.

Main Methods:

• Summarizing four SPR sensing configurations: prism, grating, waveguide, and fiber optic.
• Describing two surface plasmon excitation methods: attenuated total reflection (ATR) and diffraction.
• Detailing U-bent, tapered, and other fiber optic probe designs.

Main Results:

• Fiber optic SPR sensors demonstrate significant progress in label-free sensing.
• Review covers diverse biosensor types including immunosensors, DNA biosensors, enzyme biosensors, and living cell biosensors.
• Analysis of sensing principles and applications for each biosensor type.

Conclusions:

• Fiber optic SPR biosensors represent a significant advancement in analytical sciences.
• The technology offers versatile applications across biological and chemical sensing.
• Future developments hold promise for enhanced sensitivity and broader applications.