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Uterine Leiomyomas: An ENIGMA.
Kempula Geethamala1, Venkataramappa Srinivasa Murthy2, Bangalore Ramalingiah Vani2
1Department of Pathology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India.
Journal of Mid-Life Health
|May 3, 2016
Summary
Histopathological examination of uterine leiomyomas in hysterectomy specimens revealed common secondary changes and dual pathologies like adenomyosis. This confirms the necessity of histopathology for accurate diagnosis and management of uterine leiomyomas.
Area of Science:
- Gynecologic Pathology
- Surgical Pathology
- Reproductive Endocrinology
Background:
- Uterine leiomyomas are common benign smooth muscle tumors in women of reproductive age.
- Hormonal influence, particularly unopposed estrogen, drives leiomyoma growth and associated endometrial changes.
- Secondary changes within leiomyomas and concurrent pathologies require thorough histopathological evaluation.
Purpose of the Study:
- To investigate the spectrum of histopathological alterations in uterine leiomyomas.
- To analyze concurrent pathologies in associated endometrial and adnexal tissues.
- To underscore the importance of histopathology in managing uterine leiomyomas.
Main Methods:
- Retrospective analysis of 820 hysterectomy specimens diagnosed with uterine leiomyomas.
- Histopathological examination of surgical specimens.
- Review of clinical data from June 2010 to June 2014.
Main Results:
- Leiomyomas predominantly affected women aged 31-50 years (90.23%).
- Menorrhagia (49.36%) and pain abdomen (30.6%) were primary symptoms.
- Proliferative/hyperplastic endometrium (73.4%) and adenomyosis (29.1%) were frequent co-existing findings. Four cases showed tubercular etiology, and one had a granulosa cell tumor.
Conclusions:
- Histopathological analysis is crucial for diagnosing uterine leiomyomas and identifying associated pathologies.
- Routine hysterectomy may overlook rare tumors or infections, emphasizing the need for meticulous histopathological review.
- Accurate diagnosis through histopathology ensures optimal patient management.
