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In Vitro Cell Models for Ophthalmic Drug Development Applications.
Sara Shafaie1, Victoria Hutter1, Michael T Cook1
1Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
Bioresearch Open Access
|May 10, 2016
Summary
Tissue engineering advances in vitro eye models for drug testing. This review covers current models, their limitations, and factors for assessing ocular drug delivery and safety.
Area of Science:
- Tissue engineering
- Biomaterials science
- Ocular drug delivery
Background:
- Tissue engineering aims to create functional tissue replacements.
- In vitro organ models are crucial for drug toxicity testing.
- Ocular drug delivery requires accurate models for new therapeutics.
Purpose of the Study:
- To review existing in vitro ocular models.
- To highlight factors for using these models.
- To identify limitations in current ocular models.
Main Methods:
- Literature review of tissue engineering and ocular models.
- Analysis of physiologically accurate in vitro eye models.
- Evaluation of drug delivery and safety assessment.
Main Results:
- Several in vitro ocular models exist.
- Models vary in physiological accuracy and application.
- Key factors and limitations impact model utility.
Conclusions:
- Physiologically accurate in vitro ocular models are essential for drug development.
- Understanding model limitations is critical for reliable results.
- Further development is needed for comprehensive ocular safety assessment.
