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Manipulation of the Microbiota Using Probiotics.
Verena Grimm1, Christian U Riedel2
1Institute of Microbiology and Biotechnology, University of Ulm, Albert-Einstein-Allee 11, 89069, Ulm, Germany. verena.grimm@uni-ulm.de.
Advances in Experimental Medicine and Biology
|May 11, 2016
Summary
Altered gut microbiota composition is linked to various diseases. Therapeutic strategies aim to restore a healthy microbiome using live bacteria or substances that promote beneficial microbial populations.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- Human diseases are frequently associated with changes in the body's microbiota composition.
- The causal relationship between microbiota alterations and disease is often unclear, but suggests potential for therapeutic intervention.
Purpose of the Study:
- To review current therapeutic and prophylactic strategies for manipulating a dysbiotic microbiota.
- To summarize data on microbiome manipulation for various diseased states.
Main Methods:
- Review of existing literature on microbiome manipulation.
- Analysis of therapeutic approaches including administration of live bacteria or substances to modulate microbial populations.
Main Results:
- Discusses the rationale for targeting microbiota in conditions like irritable bowel syndrome, inflammatory bowel disease, necrotizing enterocolitis, atopic/allergic diseases, and infectious diarrhea.
- Highlights methods involving direct bacterial administration or indirect population modulation.
Conclusions:
- Microbiota manipulation offers a promising therapeutic avenue for a range of diseases.
- Further research into the efficacy and mechanisms of microbiome-targeted therapies is warranted.
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