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Updated: Mar 21, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes
M Yu Shkurnikov1, E N Knyazev2, D Wicklein3
1National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia. mshkurnikov@imscs.msu.ru.
Abstract:
Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial-mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).
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