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Polymorphism of sulfathiazole.

J Anwar1, S E Tarling, P Barnes

  • 1Department of Crystallography, Birkbeck College, University of London, U.K.

Journal of Pharmaceutical Sciences
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

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The polymorphism of sulfathiazole has been definitively resolved, confirming the separate existence of forms III and IV. Distinct spectral and diffraction patterns now allow for the isolation and study of pure sulfathiazole forms.

Area of Science:

  • Solid-state chemistry
  • Crystallography
  • Pharmaceutical science

Background:

  • Sulfathiazole exhibits polymorphism, with previous studies unresolved on the distinct existence of forms III and IV.
  • Understanding sulfathiazole's polymorphic forms is crucial for its pharmaceutical applications and stability.

Purpose of the Study:

  • To definitively resolve the existence of sulfathiazole forms III and IV.
  • To provide distinct characterization methods for all four known sulfathiazole polymorphs.
  • To clarify previous discrepancies in sulfathiazole polymorphism research.

Main Methods:

  • Single-crystal X-ray diffraction using a Gandolfi camera.
  • Powder X-ray diffraction (PXRD) analysis.
  • Infrared (IR) spectroscopy, Raman spectroscopy, and 13C Nuclear Magnetic Resonance (NMR) spectroscopy.

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Main Results:

  • The separate existence of sulfathiazole forms III and IV has been definitively confirmed.
  • Distinct X-ray diffraction patterns were obtained for single crystals of forms III and IV, matching theoretical calculations.
  • Previously observed disagreements were attributed to inadequate characterization techniques and mixed-sample analysis.

Conclusions:

  • Sulfathiazole forms III and IV are distinct and can be identified.
  • The reported spectral and PXRD data provide unique fingerprints for each of the four sulfathiazole forms.
  • This work enables confident isolation and study of pure sulfathiazole polymorphs and their relationships.