[SURGICAL TREATMENT OF ACUTE CHOLANGITIS IN CHOLEDOCHOLITHIASIS]

Area of Science:

• Gastroenterology and Hepatology
• Surgical Gastroenterology
• Clinical Diagnostics

Background:

• Choledocholithiasis frequently causes obstructive jaundice and acute cholangitis, necessitating surgical intervention.
• Accurate diagnosis and severity assessment of acute cholangitis are crucial for effective patient management.
• Understanding postoperative sequelae, including hepatic function and inflammatory markers, is vital.

Purpose of the Study:

• To analyze surgical outcomes for obstructive jaundice and acute cholangitis in patients with choledocholithiasis.
• To evaluate the diagnostic and prognostic accuracy of Tokyo Guidelines (2013) for acute cholangitis.
• To assess the dynamics of postoperative laboratory parameters and their correlation with disease severity.

Main Methods:

• Retrospective analysis of surgical treatment data from 184 patients.
• Diagnosis of acute cholangitis based on Tokyo Guidelines (2013) criteria.
• Monitoring of postoperative laboratory parameters, including hepatic function tests and hematological indices.

Main Results:

• Acute cholangitis was diagnosed in 33.7% of the studied patients.
• Obstructive jaundice and cholangitis are associated with significant hepatic dysfunction, persisting even after bile outflow restoration.
• Hematological indices, particularly the intoxication index, effectively reflect the severity of the inflammatory response.

Conclusions:

• Surgical treatment for obstructive jaundice and acute cholangitis requires careful monitoring of hepatic function.
• The Tokyo Guidelines (2013) provide a reliable framework for diagnosing and assessing acute cholangitis severity.
• The intoxication index is a key hematological marker for evaluating inflammation in these patients.