Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapy changes in the treatment of subglottic laryngitis: A 30-year experience in Croatia.

International journal of pediatric otorhinolaryngology·2026
Same author

A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth.

Cell reports·2026
Same author

The prenatal sex steroid theory of autism after 25 years.

Nature human behaviour·2026
Same author

Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids.

Journal of neurochemistry·2026
Same author

Diversity and complexity in neural organoids.

FEBS letters·2026
Same author

The Use of Topical Lidocaine Versus Lidocaine Injection for Myringotomy and Ventilation Tube Insertion.

Medicina (Kaunas, Lithuania)·2026
Same journal

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis.

Cell stem cell·2026
Same journal

Human stem cell-based embryo model governance: Insights from Japan.

Cell stem cell·2026
Same journal

From reconstruction to intervention: Engineered organoids as living therapeutic depots.

Cell stem cell·2026
Same journal

Long-term lessons from MATCH01 macrophage therapy in cirrhosis.

Cell stem cell·2026
Same journal

Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities.

Cell stem cell·2026
Same journal

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.4K

Stem Cell Models of Human Brain Development.

Iva Kelava1, Madeline A Lancaster1

  • 1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, CB2 0QH Cambridge, UK.

Cell Stem Cell
|June 4, 2016
PubMed
Summary
This summary is machine-generated.

Recent stem cell advances allow in vitro modeling of human brain development. Neural rosette and organoid methods show promise but face challenges in replicating brain complexity.

Keywords:
brain organoidscerebral organoidshuman stem cellsin vitroneural developmentneural differentiationneural rosettesorganoidsstem cells

More Related Videos

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

9.5K
Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
05:40

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

4.7K

Related Experiment Videos

Last Updated: Mar 20, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.4K
A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

9.5K
Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro
05:40

Robust and Highly Reproducible Generation of Cortical Brain Organoids for Modelling Brain Neuronal Senescence In Vitro

Published on: May 5, 2022

4.7K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Pluripotent stem cell technologies have advanced significantly.
  • Neural differentiation methods have improved, enabling better brain modeling.
  • In vitro systems now closely mimic in vivo brain development features.

Purpose of the Study:

  • To describe advances in in vitro human brain development modeling.
  • To compare neural rosette and organoid approaches.
  • To discuss challenges and solutions for recreating brain complexity in culture.

Main Methods:

  • Utilizing pluripotent stem cells for neural differentiation.
  • Developing and refining neural rosette culture systems.
  • Generating and analyzing brain organoids.

Main Results:

  • In vitro systems demonstrate remarkable similarity to in vivo brain development.
  • Neural rosette and organoid methods show distinct capabilities and limitations.
  • Current methods struggle to fully replicate the brain's cell-type complexity and spatial architecture.

Conclusions:

  • In vitro systems offer powerful tools for studying human brain development.
  • Further technical innovations are needed to overcome limitations in current models.
  • Addressing these hurdles will enhance the functional modeling of the human brain.