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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
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[Intraoperative Optical Coherence Tomography In Deep Anterior Lamellar Keratoplasty]
S Siebelmann1, P Steven1, C Cursiefen1
1Zentrum für Augenheilkunde, Universitätsklinikum Köln.
Summary
Intraoperative optical coherence tomography (iOCT) visualizes all steps of deep anterior lamellar keratoplasty (DALK). This real-time monitoring aids depth estimation and interface fluid visualization during DALK surgery.
Area of Science:
- Ophthalmology
- Surgical Technology
- Medical Imaging
Background:
- Deep anterior lamellar keratoplasty (DALK) is a standard treatment for corneal conditions like keratoconus.
- Intraoperative optical coherence tomography (iOCT) offers real-time surgical monitoring.
- iOCT is particularly useful when anterior chamber visualization is limited or precise distance estimation is needed.
Purpose of the Study:
- To evaluate the utility of intraoperative optical coherence tomography (iOCT) in deep anterior lamellar keratoplasty (DALK).
- To assess the visualization capabilities of iOCT during various stages of DALK surgery.
Main Methods:
- Literature review of studies from 2005-2016 using keywords: "intraoperative Optical Coherence Tomograph", "DALK", "Deep anterior lamellar keratoplasty", and "iOCT".
- Inclusion of own clinical and experimental data.
Main Results:
- Intraoperative OCT successfully visualized all surgical steps during DALK procedures.
- iOCT enabled accurate depth estimation during deep needle insertion.
- Visualization of intraoperative interface fluid was achieved using iOCT.
Conclusions:
- Intraoperative OCT enhances standardization of critical steps in DALK surgery.
- Further research is recommended to compare the safety of iOCT-guided DALK with conventional methods.

