Related Experiment Video

Updated: Mar 18, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.3K

Noncoding RNAs in Therapeutic Resistance of Cancer

Lintao Jia1, Angang Yang2

  • 1Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China. jialth@fmmu.edu.cn.

Advances in Experimental Medicine and Biology
|July 5, 2016
PubMed

Insights

Noncoding RNAs (ncRNAs) drive cancer therapeutic resistance by altering gene expression and cell signaling. Understanding these ncRNA mechanisms can lead to new strategies to improve cancer drug effectiveness.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer therapies face challenges due to acquired resistance.
  • Noncoding RNAs (ncRNAs) are increasingly recognized for their role in cancer progression and treatment response.

Purpose of the Study:

  • To elucidate the mechanisms by which ncRNAs contribute to cancer therapeutic resistance.
  • To explore the potential of targeting ncRNAs for overcoming drug resistance in cancer treatment.

Main Methods:

  • Review and synthesis of current literature on ncRNA function in cancer.
  • Analysis of ncRNA-mediated signaling pathways involved in drug resistance.
  • Examination of ncRNA roles in drug accessibility and metabolism.

Main Results:

  • Aberrant ncRNA expression can mediate cellular signaling that counteracts therapeutic effects.
  • ncRNAs influence drug accessibility and metabolism, impacting treatment efficacy.
  • Dysregulation of ncRNAs in cancer stroma also affects therapeutic responsiveness.

Conclusions:

  • ncRNAs are critical regulators of cancer therapeutic resistance through diverse molecular mechanisms.
  • Targeting ncRNA-related pathways presents a promising avenue for developing novel drug-sensitizing strategies.
  • Further research into ncRNA biology is essential for advancing cancer therapy.
Keywords:
ABC transporterChemotherapyDrug accessibilityDrug resistanceNoncoding RNARadiotherapyTargeted therapyTumor microenvironment

More Related Videos

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

14.5K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.2K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.7K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
15.6K