[Disseminated necrobiotic xanthogranuloma]
M Klingner1, G Hansel1, J Schönlebe2
1Klinik für Dermatologie und Allergologie, Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum, Akademisches Lehrkrankenhaus der TU Dresden, Friedrichstr. 41, 01067, Dresden, Deutschland.
Summary
Necrobiotic xanthogranuloma, a rare histiocytosis, presented as skin lesions in a 62-year-old woman. Treatment involved a combination of systemic and topical corticosteroids for this xanthogranulomatous condition.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Necrobiotic xanthogranuloma (NXG) is a rare, non-Langerhans-cell histiocytosis.
- NXG is characterized by xanthogranulomatous lesions and is often associated with monoclonal gammopathy.
Observation:
- A 62-year-old woman presented with periorbital and extremity lesions, including a nodular tumor resembling keratoacanthoma.
- Histopathological examination confirmed a xanthogranulomatous lesion.
Findings:
- The patient had κ-type monoclonal gammopathy of unknown significance.
- The clinical presentation mimicked other skin conditions, highlighting the importance of histological diagnosis.
Implications:
- Early diagnosis and appropriate management of NXG are crucial.
- Combination therapy with systemic and topical corticosteroids can be effective in treating NXG.
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