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Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery
Published on: September 30, 2021
Safety of Secretin Administration in Children
Karoly Horvath1, Beth Loveridge-Lenza, B Randall Brenn
1From the *Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA; †Division of Gastroenterology and Nutrition, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE; ‡Center for Pediatric Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL; §K. Hovnanian Children's Hospital, Jersey Shore University Hospital, Neptune, NJ; ∥Department of Anesthesia, Thomas Jefferson University, Philadelphia, PA; and ¶Departments of Anesthesia and Biomedical Research and #Gastroenterology Laboratory, Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.
Objective:
The aim of this study was to compare the hemodynamic parameters from the anesthesia records of children who underwent upper gastrointestinal endoscopy (esophagogastroduodenoscopy [EGD]) with and without secretin pancreatic function tests (sPFTs).
Methods:
The hemodynamic parameters were retrieved from an electronic anesthesia database. The secretin group consisted of 186 children, and the age- and sex-matched control group included 136 patients who did not have sPFTs.
Results:
There was no difference in the demographic parameters (age and sex) between the 2 groups. The secretin group had a lower height and body mass index. The sPFT resulted in an average 3-minute extension of the endoscopic procedure. The heart rate increased during the EGD in both groups and was higher (averaged 7 beats per minute) in the secretin group than the EGD-only group. There were mild elevations on the systolic and diastolic blood pressures. None of these changes were clinically significant. There were no complications reported during the anesthesia and procedures in the 2 groups.
Conclusions:
Secretin PFT is a safe procedure. It only slightly prolongs the total procedure and anesthesia time. There were no clinically significant changes in the vital parameters in the secretin group, and there were no adverse effects recorded.
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