Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

79
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
79
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

101
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
101
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

162
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
162
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

72
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
72
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

82
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
82
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

192
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
192

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A change in ligand hapticity promotes Lewis base dissociation.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Ultralong Hydroxyapatite Nanowires: Promising Flexible Building Blocks for Constructing High-Performance Biomimetic Materials-A Review.

Molecules (Basel, Switzerland)·2026
Same author

Bioactive Multifunctional Hydrogel Scaffolds Remodel the Inflammatory Microenvironment and Osteogenic-Osteoclastic Homeostasis to Advance Osteoporotic Bone Defect Repair.

ACS nano·2025
Same author

A Local Structure Analysis of Defects in UiO-66: Insights from Solid-State Nuclear Magnetic Resonance and X-ray Absorption Fine Structure.

Journal of the American Chemical Society·2025
Same author

Anion sublattice design enables superionic conductivity in crystalline oxyhalides.

Science (New York, N.Y.)·2025
Same author

An active bifunctional natural dye for stable all-solid-state organic batteries.

Nature communications·2025
Same journal

Dry powder inhaler selection in COPD: integrating device design, formulation performance, and patient inspiratory capability.

Expert opinion on drug delivery·2026
Same journal

Letter to the Editor: 'saving money but costing lives: the lack of integrated dose counters on pressurised metered dose inhalers'.

Expert opinion on drug delivery·2026
Same journal

Response to letter to the editor: 'Saving money but costing lives: the lack of integrated dose counters on pressurised metered dose inhalers'.

Expert opinion on drug delivery·2026
Same journal

Mechanism-guided metal complex therapeutics for biofilm-driven wound infections and transdermal delivery.

Expert opinion on drug delivery·2026
Same journal

Next-generation strategies for PROTAC formulation: mechanistic insights and advanced formulation technologies.

Expert opinion on drug delivery·2026
Same journal

Drug penetration in solid tumors: influence of drug size and capillary architecture.

Expert opinion on drug delivery·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.6K

Calcium silicate-based drug delivery systems.

Ying-Jie Zhu1, Xiao-Xuan Guo2, Tsun-Kong Sham2

  • 1a State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics , Chinese Academy of Sciences , Shanghai , P. R. China.

Expert Opinion on Drug Delivery
|July 20, 2016
PubMed
Summary
This summary is machine-generated.

Calcium silicate nanomaterials offer superior biocompatibility and controlled release for drug delivery systems. Their unique properties enable prolonged therapeutic effects and targeted delivery, paving the way for advanced medical treatments.

Keywords:
Calcium silicatedrug deliverynanostructured materialssynchrotron spectroscopy

More Related Videos

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
09:44

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

692

Related Experiment Videos

Last Updated: Mar 17, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

11.6K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.8K
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
09:44

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

692

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Calcium silicate materials, particularly nanostructured forms, exhibit excellent biocompatibility, bioactivity, and biodegradability.
  • These materials possess high specific surface area, nanoporous/hollow structures, and significant drug-loading capacity.
  • Their pH-responsive drug release behavior makes them highly promising for advanced drug delivery applications.

Purpose of the Study:

  • To highlight the potential of calcium silicate-based drug delivery systems.
  • To present examples from recent literature and new molecular-level insights.
  • To provide expert opinions and propose future research directions.

Main Methods:

  • Literature review of calcium silicate-based drug delivery systems.
  • Analysis of molecular interactions between drugs and calcium silicate carriers.
  • Utilizing synchrotron-based X-ray spectroscopy for detailed investigations.

Main Results:

  • Calcium silicate drug delivery systems demonstrate prolonged drug release, extending therapeutic effects.
  • The pH-responsive nature of these systems facilitates targeted drug delivery.
  • Synchrotron-based X-ray spectroscopy provided novel insights into drug-carrier interactions at the molecular level.

Conclusions:

  • Calcium silicate-based materials are highly promising for drug delivery due to their favorable properties.
  • These systems offer advantages in terms of therapeutic duration and targeted delivery.
  • Further research, guided by molecular-level understanding, is recommended to optimize their clinical application.