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Updated: Mar 17, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
syn-Bimane as a chelating O-donor ligand for palladium(ii)
Partha Jyoti Das1, Yael Diskin-Posner2, Michael Firer3
1Department of Chemical Sciences, Ariel University, Ariel 40700, Israel. flaviog@ariel.ac.il michaelmo@ariel.ac.il.
Abstract:
A cationic Pd(ii) complex containing syn-(Me,Me)bimane as a ligand was prepared and fully characterized. This complex represents the first well-defined case of a bimane scaffold coordinated to a metal center. The strongly-fluorescent syn-bimane chelates the Pd(ii) center via its carbonyl oxygen atoms, affording a non-fluorescent complex. The crystal structure of this complex shows that the coordinated bimane departs from planarity, with its bicyclic framework bent about the N-N bond. Spectroscopic evidence demonstrates that bimane coordination is reversible in solution.
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