[THE OBESITY IMPACT ON INFLAMMATORY MARKERS IN PATIENTS WITH ARTERIAL HYPERTENSION]

Area of Science:

• Immunology
• Cardiology
• Endocrinology

Background:

• Arterial hypertension (AH) and obesity are significant global health concerns.
• Both conditions are associated with chronic low-grade inflammation.
• The interplay between AH, obesity, and specific inflammatory markers requires further elucidation.

Purpose of the Study:

• To investigate the concentrations of C-reactive protein (CRP), IL-1β, and IL-4 in patients with arterial hypertension and obesity.
• To compare inflammatory profiles between hypertensive patients with and without obesity.

Main Methods:

• Study included 64 patients with hypertension (II degree), divided into groups with (n=39) and without (n=25) obesity.
• Obesity assessment included body mass index and waist-to-hip ratio.
• Serum cytokine levels (IL-1β, IL-4) were measured using ELISA kits; CRP levels were determined using a commercial kit.

Main Results:

• Hypertension with obesity demonstrated significantly elevated levels of CRP and IL-1β compared to hypertension without obesity.
• Patients with hypertension and obesity exhibited reduced levels of the anti-inflammatory cytokine IL-4.
• A direct correlation was observed between the severity of obesity and the degree of inflammation in hypertensive patients.

Conclusions:

• Hypertension combined with obesity is characterized by heightened pro-inflammatory activity (CRP, IL-1β) and diminished anti-inflammatory responses (IL-4).
• Immunoinflammatory dysregulation plays a critical role in the pathogenesis of hypertension in obese individuals.
• Obesity exacerbates inflammation, directly impacting the severity of hypertension.