Related Experiment Video
Updated: Mar 17, 2026
09:42
Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
10.3K
mRNA methylation by NSUN2 in cell proliferation
1Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China. wwg@bjmu.edu.cn.
Wiley Interdisciplinary Reviews. RNA
|July 23, 2016
Summary
NSUN2 methylates mRNAs, influencing cell division and growth arrest. This review summarizes NSUN2
Area of Science:
- Molecular Biology
- Epigenetics
- RNA Biology
Background:
- Methylation is a key post-transcriptional RNA modification.
- NSUN2 is a crucial RNA methyltransferase involved in cellular processes.
Purpose of the Study:
- To review recent advancements in NSUN2-mediated mRNA methylation.
- To explore the role of NSUN2 in cell proliferation and senescence.
Main Methods:
- Literature review of NSUN2 research.
- Analysis of NSUN2's impact on mRNA stability and translation.
Main Results:
- NSUN2 targets mRNAs controlling cell division and growth arrest.
- NSUN2-mediated methylation affects mRNA stability and/or translation.
Conclusions:
- NSUN2 plays a significant role in regulating cell proliferation and senescence.
- Understanding NSUN2-mediated mRNA methylation is crucial for cellular regulation.
Related Concept Videos
02:23Abnormal Proliferation
5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
02:55The Nucleolus
10.6K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.6K
01:46Epigenetic Regulation
34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
01:37Epigenetic Regulation
4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
4.1K
01:28Biosynthesis of Nucleic Acids
1.4K
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.4K
01:22MicroRNAs
4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K