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Updated: Mar 16, 2026
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Published on: April 5, 2016
Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits
Elisabeth Vogel1, Sabine Krabbe2, Jan Gründemann2
1Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland; University of Basel, 4000 Basel, Switzerland.
Abstract:
Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory micro-circuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.
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