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Pharmacogenomics in Psychiatric Practice
Rif S El-Mallakh1, R Jeannie Roberts2, Peggy L El-Mallakh3
1Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville HealthCare OutPatient Center, University of Louisville School of Medicine, 401 East Chestnut Street, Suite 610, Louisville, KY 40202, USA.
Abstract:
Pharmacogenomic testing in psychiatry is becoming an established clinical procedure. Several vendors provide clinical interpretation of combinatorial pharmacogenomic testing of gene variants that have documented predictive implications regarding either pharmacologic response or adverse effects in depression and other psychiatric conditions. Such gene profiles have demonstrated improvements in outcome in depression, and reduction of cost of care of patients with inadequate clinical response. Additionally, several new gene variants are being studied to predict specific response in individuals. Many of these genes have demonstrated a role in the pathophysiology of depression or specific depressive symptoms. This article reviews the current state-of-the-art application of psychiatric pharmacogenomics.
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