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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
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Deep Venous Thrombosis and Tendon Healing.
Erica Domeij-Arverud1,2, Paul W Ackermann3,4
1Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176, Stockholm, Sweden. erica.domeij-arverud@ds.se.
Advances in Experimental Medicine and Biology
|August 19, 2016
Summary
Intermittent pneumatic compression (IPC) significantly reduces deep venous thrombosis (DVT) risk in Achilles tendon rupture (ATR) patients. This adjuvant therapy also enhances tendon healing, suggesting a dual benefit for patient recovery.
Area of Science:
- Orthopedics
- Vascular Surgery
- Biomedical Engineering
Background:
- Immobilization after Achilles tendon rupture (ATR) leads to complications like deep venous thrombosis (DVT), impaired healing, and functional deficits.
- DVT occurs in up to 50% of ATR patients and independently predicts poor outcomes, necessitating effective prevention strategies.
- Pharmacological DVT prophylaxis shows limited efficacy during lower leg immobilization, prompting investigation into alternative methods.
Purpose of the Study:
- To evaluate the efficacy of intermittent pneumatic compression (IPC) as an adjuvant therapy to prevent DVT in patients with ATR.
- To assess the impact of IPC on tendon healing and metabolic activity during immobilization.
Main Methods:
- A prospective randomized trial comparing adjuvant IPC applied under an orthosis versus a plaster cast alone in ATR patients.
- Assessment of DVT incidence at 2 weeks post-operatively.
- Microdialysis technique to measure metabolic healing activity at 2 weeks post-ATR.
Main Results:
- The IPC group showed a DVT incidence of 21% compared to 37% in the control group.
- Patients without IPC had a threefold increased odds for DVT, irrespective of age.
- Adjuvant IPC treatment increased metabolic healing activity at 2 weeks post-ATR.
Conclusions:
- Adjuvant IPC effectively reduces DVT incidence in ATR patients undergoing immobilization.
- IPC may promote tendon healing by enhancing metabolic activity, in addition to DVT prophylaxis.
- IPC represents a promising therapeutic option for improving outcomes in Achilles tendon rupture recovery.
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