Related Experiment Video
Updated: Mar 16, 2026
06:06
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
3.3K
Oral Lichen Planus Treated With Apremilast
Journal of Drugs in Dermatology : JDD
|August 19, 2016
Summary
Oral lichen planus is difficult to treat, causing pain and eating issues. Three recalcitrant cases showed effective treatment with apremilast, improving patient quality of life.
Area of Science:
- Dermatology
- Oral Medicine
Background:
- Oral lichen planus (OLP) presents significant treatment challenges, impacting patient quality of life due to pain and eating difficulties.
- Current therapies, primarily topical, often lack efficacy in severe OLP cases.
- Systemic treatments for OLP are associated with adverse effects, monitoring needs, and cost concerns.
Observation:
- Three patients with recalcitrant oral lichen planus were treated.
- Apremilast, a medication approved for psoriasis and psoriatic arthritis, was administered.
Findings:
- All three cases of recalcitrant oral lichen planus demonstrated effective treatment outcomes with apremilast.
- The use of apremilast led to symptom relief and improved patient well-being.
Implications:
- Apremilast shows promise as an effective treatment option for severe and refractory oral lichen planus.
- This suggests a potential new therapeutic avenue for managing challenging OLP cases.
- Further research into apremilast for OLP is warranted to confirm these findings.
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
2.1K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.1K
01:29Drugs for Treatment of Ulcerative Colitis in IBD
592
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
592
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
582
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
582
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.8K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.8K