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Engineering Synthetically Modified Insulin for Glucose-Responsive Diabetes Therapy.

Matthew J Webber1, Daniel G Anderson2, Robert Langer2

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA; Department of Anesthesiology, Boston Children's Hospital, Boston, MA 02115, USA.

Expert Review of Endocrinology & Metabolism
|August 30, 2016
PubMed
Summary

Researchers developed glucose-responsive insulin by modifying it with phenylboronic acid. This modification allows insulin to adjust its action based on glucose levels, improving diabetes therapy and reducing hypoglycemia risk.

Keywords:
Concanavalin Abioartificial pancreasbionic pancreasdiabetesdrug deliveryfully synthetic pancreaslectinphenylboronic acid

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