Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Massive levothyroxine ingestion. Conservative management.

S H Mandel1, A R Magnusson, B T Burton

  • 1Doernbecher Memorial Hospital for Children, Oregon Health Sciences University, Portland.

Clinical Pediatrics
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of a multidisciplinary guideline improves preterm infant admission temperatures.

Journal of perinatology : official journal of the California Perinatal Association·2017
Same author

Roadmap to a successful quality improvement project.

Journal of perinatology : official journal of the California Perinatal Association·2016
Same author

Antenatal corticosteroids before 24 weeks: is it time?

Journal of perinatology : official journal of the California Perinatal Association·2016
Same author

The complete blood cell count in a refined cohort of preterm NEC: the importance of gestational age and day of diagnosis when using the CBC to estimate mortality.

Journal of perinatology : official journal of the California Perinatal Association·2015
Same author

Surgical necrotizing enterocolitis defined.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same author

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.

Journal of perinatology : official journal of the California Perinatal Association·2014
Same journal

Effect of Preferred Language on Pediatric Rapid Response Activation and Subsequent Intensive Care Utilization.

Clinical pediatrics·2026
Same journal

Documented Caregiver Report of Wheezing at Home is Associated With Decreased Length of Pediatric Asthma Hospitalizations.

Clinical pediatrics·2026
Same journal

The Rash That Will Not Go Away.

Clinical pediatrics·2026
Same journal

Virtual Reality Education for Hospitalized Pediatric Patients Improves Intrinsic Motivation: A Prospective, Randomized Crossover Study.

Clinical pediatrics·2026
Same journal

Pediatric Invasive Group A Streptococcus Characteristics Before, During, and After COVID-19.

Clinical pediatrics·2026
Same journal

Lichen Sclerosus: A Common but Often Overlooked Condition in Pediatric Patients.

Clinical pediatrics·2026
See all related articles

A child

Area of Science:

  • Pediatric Endocrinology
  • Clinical Toxicology

Background:

  • Levothyroxine (T4) overdose in children presents a unique clinical challenge.
  • Assessing the severity and management of acute levothyroxine ingestion is crucial for pediatric care.

Observation:

  • A 29-month-old girl ingested 90 tablets (18 mg) of levothyroxine.
  • Despite significantly elevated initial thyroxine (T4) and triiodothyronine (T3) levels, clinical symptoms were mild, including irritability, vomiting, tremor, and tachycardia.
  • Treatment involved activated charcoal and propranolol.

Findings:

  • Thyroid hormone levels normalized within 13 days post-ingestion.
  • The child experienced a benign clinical course.
  • Mild symptoms in children following massive levothyroxine ingestion are common.

Related Experiment Videos

Implications:

  • Propranolol can effectively manage symptoms of acute levothyroxine overdose in children.
  • A conservative management approach is recommended, avoiding aggressive or potentially harmful therapies.
  • This case highlights the generally mild clinical outcomes in pediatric levothyroxine ingestions.