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Related Experiment Video

Updated: Jan 14, 2026

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

Advanced Technologies Lead iNto New Reprogramming Routes.

Yang Zhou¹, Li Qian¹

¹Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

|September 3, 2016

Summary

This summary is machine-generated.

New research reveals the dynamic processes of transcriptional changes and epigenetic remodeling during induced neuron (iN) reprogramming. These studies offer insights into the cellular pathways involved in converting cells into neurons.

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Last Updated: Jan 14, 2026

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

Published on: November 26, 2018

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Kinetic Measurement and Real Time Visualization of Somatic Reprogramming

Published on: July 30, 2016

Area of Science:

Neuroscience
Stem Cell Biology
Epigenetics

Background:

Induced neurons (iNs) offer a model for studying neuronal development and disease.
Understanding the dynamics of cellular reprogramming is crucial for regenerative medicine.

Purpose of the Study:

To investigate transcriptional dynamics during induced neuron reprogramming.
To explore epigenetic remodeling during the conversion of cells into neurons.

Main Methods:

Single-cell transcriptomics to map cellular trajectories.
Gene editing to activate endogenous reprogramming factor loci.

Main Results:

Identified distinct routes and intermediate stages in early iN induction.
Demonstrated the role of endogenous gene activation in reprogramming efficiency.

Conclusions:

Reprogramming to induced neurons involves complex transcriptional and epigenetic changes.
These findings advance our understanding of cell fate determination and neuronal differentiation.