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18, 19-Dihydroxycorticosterone: a new metabolite in human urine
J Godzsa1, P Vecsei, T Iwuanyanwu
1Department of Pharmacology, University of Heidelberg, W. Germany.
Endocrine Research
|January 1, 1989
Abstract:
Urines of patients with primary aldosteronism were extracted, the extract repeatedly chromatographed with reversed phase HPLC. The fractions immunoactive against 18-hydroxycorticosterone antiserum and being more polar than the 18-hydroxycorticosterone were further purified, derivatized and investigated by GC/MS. In this manner the natural occurrence of the 18, 19-dihydroxycorticosterone, which was lately synthetized, in human urine was confirmed.