Related Experiment Video
Updated: Mar 15, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot
Lin Chen1, Jianpan Huang2, Ting Zhang2
1Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices, Department of Electronic Science, Xiamen University, Xiamen 361005, China; Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
Variable density spiral trajectories and non-Cartesian reconstruction enhance Spatiotemporally encoded (SPEN) MRI. This ultrafast technique improves spatial resolution and reduces aliasing artifacts for better imaging.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Medical Imaging Technology
Background:
- Spatiotemporally encoded (SPEN) single-shot MRI is an ultrafast imaging technique.
- Variable density sampling offers advantages over uniform sampling in MRI, potentially reducing artifacts and increasing efficiency.
Purpose of the Study:
- To develop and evaluate a variable density spiral trajectory combined with non-Cartesian super-resolved (SR) reconstruction for SPEN MRI.
- To optimize gradient waveform design for spiral trajectories within hardware constraints.
Main Methods:
- Designed a variable density spiral trajectory optimized for hardware limitations.
- Developed a non-Cartesian SR reconstruction method using a specific gridding approach for SPEN data.
- Validated the methods through numerical simulations and experimental imaging.
Main Results:
- Variable density SPEN MRI demonstrated improved spatial resolution compared to Cartesian methods.
- The proposed technique effectively reduced aliasing artifacts.
- Numerical simulations and experiments confirmed the robustness and efficiency of the developed methods.
Conclusions:
- Variable density SPEN MRI with spiral trajectories and non-Cartesian SR reconstruction offers superior performance.
- The developed methods enhance image quality by improving resolution and minimizing artifacts.
- This approach facilitates advancements in variable density SPEN MRI applications.
Related Concept Videos
Electron Microscope Tomography and Single-particle Reconstruction
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Super-resolution Fluorescence Microscopy

