Potentiometric sensor fabrication having 2D sarcosine memories and analytical features

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Materials Science

Background:

• Prostate cancer diagnosis relies on identifying specific biomarkers.
• Sarcosine is a key metabolite linked to prostate cancer progression.
• Developing sensitive and selective detection methods for sarcosine is crucial.

Purpose of the Study:

• To develop and validate a novel molecularly imprinted polymeric sensor.
• To enable rapid and sensitive determination of sarcosine as a prostate cancer biomarker.

Main Methods:

• Synthesized molecularly imprinted polymer (MIP) using emulsion polymerization.
• Employed sarcosine as the template molecule, MAH as the functional monomer, and EDMA as the cross-linking agent.
• Evaluated sensor performance using potentiometric measurements.

Main Results:

• Fabricated a sensitive potentiometric sensor for sarcosine detection.
• Achieved high selectivity, a short response time (<2 min), and a wide linear range (10⁻²–10⁻⁶ mM).
• Demonstrated a low detection limit (1.35 × 10⁻⁷ mM) and long-term stability (>5.5 months).

Conclusions:

• The developed MIP sensor provides a simple, rapid, and sensitive method for prostate cancer biomarker determination.
• The sensor's high performance characteristics make it suitable for clinical applications.
• This technology holds promise for improved prostate cancer diagnostics.