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Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
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Approach to Management of Eyes with no Light Perception after Open Globe Injury
Neelakshi Bhagat1, Roger Turbin1, Paul Langer1
1Rutgers-Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Journal of Ophthalmic & Vision Research
|September 14, 2016
Summary
Loss of light perception after open globe injury doesn't always mean permanent blindness. Factors like optic nerve damage and severe eye content loss predict poor outcomes, but some patients may regain vision with further treatment.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Medical Imaging
Background:
- Open globe injury (OGI) can lead to severe vision loss, including loss of light perception (LP).
- The prognosis for vision recovery after OGI with initial LP is often uncertain.
- Predicting the likelihood of permanent profound vision loss is crucial for patient management.
Purpose of the Study:
- To identify factors reliably associated with permanent profound vision loss after OGI.
- To determine criteria for considering additional surgical intervention in eyes with NLP post-OGI.
- To counsel patients on the realistic chances of visual recovery.
Main Methods:
- Review of clinical findings and imaging (CT/MRI) in patients with OGI and LP.
- Analysis of outcomes following primary repair and, in select cases, further surgical procedures.
- Correlation of specific injury characteristics with final visual acuity.
Main Results:
- Optic nerve avulsion, optic nerve transection, and profound loss of intraocular contents are associated with permanent profound vision loss.
- Successful primary repair with intact optic nerves may warrant further surgery if LP recovers post-op, treatable pathology exists, or the fellow eye is also affected.
- The chance of recovering ambulatory vision in such cases is approximately 5%.
Conclusions:
- While initial loss of light perception after OGI is serious, it does not always equate to irreversible blindness.
- Specific imaging findings and early post-operative responses are key indicators for prognosis and treatment decisions.
- Aggressive management strategies offer a small but potential window for visual recovery in carefully selected OGI patients.
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