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Advances in Anticancer Protein Delivery Using Micro-/ Nanoparticles

Wujin Sun1, Yue Lu1, Zhen Gu1

  • 1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA; Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Particle & Particle Systems Characterization : Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems
|September 20, 2016
PubMed

Insights

Researchers are exploring protein-based therapies to target cancer cells selectively. This review covers advanced delivery methods for anticancer proteins to tumors and immune cells, discussing various carriers and future directions.

Area of Science:

  • Biotechnology
  • Oncology
  • Drug Delivery

Background:

  • Proteins with selective cancer cell-killing abilities are crucial for novel anticancer therapeutics.
  • Directing these proteins to tumor sites or immune cells enhances therapeutic efficacy.

Purpose of the Study:

  • To review recent advancements in the delivery of anticancer proteins.
  • To discuss various protein delivery carriers and their associated benefits and drawbacks.

Main Methods:

  • Survey of current literature on protein-based anticancer drug delivery.
  • Analysis of different types of delivery vehicles, including inorganic, lipid, polymeric, DNA/protein, and cell-based carriers.

Main Results:

  • Various carriers show promise for targeted delivery of anticancer proteins.
  • Each carrier type presents unique advantages and limitations for therapeutic application.

Conclusions:

  • Targeted delivery of anticancer proteins is a rapidly advancing field with significant therapeutic potential.
  • Further research is needed to overcome challenges and optimize protein delivery systems for cancer treatment.

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