Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 14, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.0K

ProFold: Protein Fold Classification with Additional Structural Features and a Novel Ensemble Classifier.

Daozheng Chen1, Xiaoyu Tian1, Bo Zhou2

  • 1College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China.

Biomed Research International
|September 24, 2016
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Protein Folding01:22

Protein Folding

36.1K
36.1K
Protein Folding01:22

Protein Folding

129.8K
Overview
129.8K
Protein Folding01:25

Protein Folding

12.1K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
12.1K
Protein and Protein Structure02:15

Protein and Protein Structure

91.3K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
91.3K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.9K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.9K
Protein Organization01:13

Protein Organization

160.7K
Overview
160.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Latent Oncogenes with a Network Embedding Method and Random Forest.

BioMed research international·2020
Same journal

Evaluating a Novel Cell-Free Preservation Solution for Human Cardiomyocyte Protection: A Proof-of-Concept Study.

BioMed research international·2026
Same journal

Clinical Efficacy of Chinese Medicine in Treating Adult Henoch-Schönlein Purpura: A Meta-Analysis.

BioMed research international·2026
Same journal

RETRACTION: Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the Sirt1 Signaling Pathway.

BioMed research international·2026
Same journal

The Oncogenic and Tumor-Suppressive Roles of SNHG18: A Double-Edged Long Noncoding RNA in Cancer.

BioMed research international·2026
Same journal

Evaluation of LncRNA NEAT1 and MEG3 Expression Levels in Hospitalized COVID-19 Patients.

BioMed research international·2026
Same journal

Perceived Self-Efficacy and Its Determinants for Noncommunicable Disease Prevention Among Adults in Southern Ethiopia: A Community-Based Cross-Sectional Study.

BioMed research international·2026
See all related articles

A new protein fold classification method, proFold, was developed for efficient analysis. It achieves high accuracy on benchmark datasets, aiding protein function studies and drug design.

Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Protein science

Background:

  • Protein fold classification is crucial for understanding protein function and enabling drug design.
  • The Protein Data Bank (PDB) contains vast protein structural data, but only a fraction is classified in databases like SCOPe.
  • Developing efficient protein fold classification methods is essential due to the growing volume of protein data.

Purpose of the Study:

  • To introduce proFold, a novel and efficient method for protein fold classification.
  • To improve upon existing protein fold classification techniques using advanced feature extraction and ensemble strategies.

Main Methods:

  • ProFold incorporates protein tertiary structure information during feature extraction.
  • A novel ensemble strategy is employed for classifier training in the proFold method.

More Related Videos

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.7K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

70.0K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.7K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
  • The method was evaluated on widely used datasets: DD-dataset, EDD-dataset, and TG-dataset.

    • Main Results:

    • ProFold achieved 76.2% overall accuracy on the DD-dataset, outperforming existing ensemble classifiers.
    • On the EDD-dataset and TG-dataset, proFold demonstrated high accuracies of 93.2% and 94.3%, respectively.
    • These results indicate superior performance compared to existing methods on these benchmark datasets.

    Conclusions:

    • ProFold offers a highly accurate and efficient approach to protein fold classification.
    • The method's performance on multiple datasets suggests its robustness and broad applicability.
    • ProFold is publicly accessible as a web server, facilitating its use in research and development.