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Related Experiment Video

Updated: Mar 14, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Balancing the 2 Hemispheres in Simple Calculation: Evidence From Direct Cortical Electrostimulation.

C Semenza^1,2, E Salillas³, S De Pallegrin⁴

¹Neuroscience Department and Centre for Cognitive Neuroscience, University of Padova, 35128 Padova, Italy.

Cerebral Cortex (New York, N.Y. : 1991)

|September 25, 2016

Summary

This summary is machine-generated.

Direct brain stimulation reveals distinct roles for the left and right parietal lobes in calculation. The left hemisphere aids rote retrieval, while the right supports approximation for accurate math.

Keywords:

approximation brain mapping exact calculation hemispheric complementarity parietal lobe

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Area of Science:

Neuroscience
Cognitive Psychology
Neurosurgery

Background:

The precise roles of the parietal lobes in simple calculation remain unclear, with conflicting evidence from correlational studies.
Previous research using clinical and neuroimaging methods has not definitively established hemispheric contributions to mathematical processing.

Purpose of the Study:

To causally investigate the contribution of the left and right parietal lobes to simple calculation using direct cortical electrostimulation.
To differentiate the specific functions of each parietal lobe during mathematical tasks.

Main Methods:

Direct cortical electrostimulation was applied during brain surgery to patients performing simple calculations.
A novel qualitative error analysis was employed to categorize errors induced by stimulation.

Main Results:

Stimulation of both left and right parietal areas induced calculation errors (addition and multiplication).
Inhibiting the left hemisphere primarily resulted in approximation errors.
Inhibiting the right hemisphere led to enhanced retrieval errors from a stored repertoire.

Conclusions:

The left parietal lobe is crucial for the rote retrieval of potential solutions in calculation.
The right parietal lobe plays a key role in approximating the correct answer.
Precise calculation relies on the coordinated interaction between the approximation function of the right hemisphere and the retrieval function of the left hemisphere.