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Curcumin and Its Role in Chronic Diseases
1Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
Advances in Experimental Medicine and Biology
|September 28, 2016
Summary
Curcumin, a compound from turmeric, shows significant antioxidant and anti-inflammatory properties. Its potential as a safe and inexpensive therapeutic agent for various diseases, including cancer, is being explored in clinical trials.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Medicinal Chemistry
Background:
- Curcumin, a natural pigment from turmeric, has a long history of use in traditional Indian and Chinese medicine.
- Decades of research have validated curcumin's potential as a significant pharmacological agent.
- Its known antioxidant, anti-inflammatory, and antimicrobial activities have spurred interest in its therapeutic applications.
Purpose of the Study:
- To review the pharmacological potential of curcumin.
- To highlight its efficacy in managing chronic diseases and its exploration as an anticancer agent.
- To underscore its value as an inexpensive botanical molecule with potent therapeutic abilities.
Main Methods:
- Review of extensive scientific literature over the past 3-4 decades.
- Analysis of preclinical and clinical data on curcumin's biological activities.
- Evaluation of curcumin's safety and efficacy profiles.
Main Results:
- Curcumin exhibits potent antioxidant, anti-inflammatory, antimicrobial, and chemopreventive activities.
- Promising results have been observed in exploring curcumin against various chronic diseases.
- Clinical trials are underway to investigate curcumin's efficacy as an anticancer agent, with favorable safety data up to 12 g/day.
Conclusions:
- Curcumin is a versatile botanical molecule with significant therapeutic potential.
- Its multitargeting capabilities and non-toxic nature make it an attractive candidate for drug development.
- Further research is warranted to fully understand and utilize curcumin's medicinal properties.
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