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Butein and Its Role in Chronic Diseases
Ziwei Song1, Muthu K Shanmugam2, Hanry Yu1,3,4,5
1Department of Physiology, Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore, 117597, Singapore.
Advances in Experimental Medicine and Biology
|September 28, 2016
Summary
Butein, a natural compound from medicinal plants, shows promise for treating chronic diseases with anti-inflammatory and anticancer effects. Further research into its targets and pharmacokinetics could unlock its full therapeutic potential.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Medicinal Chemistry
Background:
- Natural compounds from plants have a long history of therapeutic use.
- These compounds are increasingly recognized for efficacy and safety in managing chronic diseases.
- Butein, a chalcone, is a notable example with diverse pharmacological activities.
Purpose of the Study:
- To review the therapeutic and protective effects of butein.
- To summarize existing literature on butein's efficacy in human chronic disease models.
- To highlight areas for future research on butein's application.
Main Methods:
- Literature review of published studies on butein.
- Analysis of butein's pharmacological effects in various disease models.
- Examination of butein's cellular targets, toxicity, and pharmacokinetics.
Main Results:
- Butein exhibits significant anti-inflammatory, anticancer, antioxidant, and anti-angiogenic properties.
- These effects have been demonstrated across diverse models of human chronic diseases.
- Existing literature supports butein's therapeutic potential.
Conclusions:
- Butein is a promising natural compound for chronic disease management.
- Further investigation into its cellular targets, toxicity, and pharmacokinetics is warranted.
- Expanded research may lead to broader therapeutic applications of butein.
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