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Oral Teratoma with a Primitive Neuroectodermal Tumor Component: A Case Report
Swetha Acharya1, Amsavardani Tayaar2, Sahana Adirajaiah3
1Assistant Professor, Department of Oral Pathology, SDM College of Dental Sciences and Hospital, Karnataka, India.
International Journal of Clinical Pediatric Dentistry
|September 29, 2016
Summary
This study details a rare oral teratoma case in a child, highlighting primitive neuroectodermal tumor (PNET) arising from germ cell tumors. Microscopic findings confirmed trilineage differentiation and CD-99 positivity, aiding diagnosis.
Area of Science:
- Pediatric Oncology
- Oral Pathology
- Germ Cell Tumors
Background:
- Teratomas, germ cell tumors derived from three germ layers, are common extragonadal germ cell tumors (EGCT) in children.
- Head and neck EGCTs constitute 5% of all germ cell tumors and 6% of all teratomas.
- Primitive neuroectodermal tumor (PNET) is a distinct entity arising from malignant transformation of teratomas.
Observation:
- A rare case of oral teratoma in a 6-year-old male is presented.
- The patient presented with pain and swelling in the right upper jaw, posterior to the teeth.
- Microscopic examination revealed mature and immature tissues from all three germ layers.
Findings:
- Histopathology showed mature and immature structures representing trilineage derivatives.
- Sheets of small round cells with vague rosettes and membranous CD-99 positivity were observed.
- These findings supported the diagnosis of a teratoma with potential malignant transformation.
Implications:
- This case underscores the importance of considering teratomas in pediatric head and neck masses.
- Early diagnosis and appropriate management are crucial for outcomes in pediatric germ cell tumors.
- The presence of PNET features warrants further investigation into malignant transformation potential.
