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Updated: Mar 14, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Use of the Hydantoin Directing Group in Ruthenium(II)-Catalyzed C-H Functionalization
Jamie A Leitch1, Hans P Cook1, Yunas Bhonoah2
1Department of Chemistry, University of Bath , Claverton Down, Bath, Somerset BA2 7AY, United Kingdom.
Abstract:
Ruthenium(II)-catalyzed C-H functionalization of N-arylhydantoins is herein described. The biologically relevant hydantoin (imidazolidinedione) heterocycle functions as a weakly coordinating directing group in a C-H alkenylation reaction. The reaction gave a wide scope of 23 examples with yields up to 94% in the green solvent 2-MeTHF. Functionalization of API nilutamide (antiandrogen) is also reported. The use of the succinimide heterocycle as a directing group is also demonstrated in modest yields.
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