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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Mar 14, 2026

Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm
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Transplantation for Multiple Myeloma.

Yogesh S Jethava1, Frits van Rhee2

  • 1Stem Cell and Allogeneic Transplant, Department of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. YSJethava@uams.edu.

Cancer Treatment and Research
|October 4, 2016
PubMed
Summary
This summary is machine-generated.

Multiple myeloma treatment has advanced with new drugs, but hematopoietic stem cell transplantation remains key. This chapter reviews autologous and allogeneic stem cell transplants and total therapy trials for multiple myeloma.

Keywords:
Clinical trials with transplantMyelomaStem cell transplantTandem transplants

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Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Transplantation

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • It involves bone marrow infiltration, hypercalcemia, and organ damage.
  • Recent FDA approvals offer new therapeutic options.

Purpose of the Study:

  • To discuss current treatment modalities for multiple myeloma.
  • To review hematopoietic stem cell transplantation (HSCT) in myeloma management.
  • To analyze outcomes of autologous HSCT, allogeneic HSCT, and total therapy trials.

Main Methods:

  • Review of autologous stem cell transplant procedures.
  • Review of allogeneic stem cell transplant procedures.
  • Analysis of data from total therapy clinical trials.

Main Results:

  • Hematopoietic stem cell transplantation is a cornerstone treatment for multiple myeloma.
  • Novel agents are improving patient survival.
  • Outcomes vary across different transplant types and therapy protocols.

Conclusions:

  • While novel therapies enhance survival, HSCT remains central to multiple myeloma treatment.
  • Understanding outcomes of different HSCT approaches is crucial for patient management.
  • Further research into total therapy trials informs optimal treatment strategies.