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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Isoniazid metabolism and hepatotoxicity

Pengcheng Wang1, Komal Pradhan1, Xiao-Bo Zhong2

  • 1Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Acta Pharmaceutica Sinica. B
|October 7, 2016
PubMed
Summary

Isoniazid (INH) effectively treats tuberculosis but can cause liver injury. This review explores how INH metabolism contributes to liver damage, aiding in understanding and preventing adverse effects.

Keywords:
ALP, alkaline phosphataseALT, alanine aminotransferaseAcHz, acetylhydrazineAcINH, acetylisoniazidAmidaseAnti-tuberculosisDiAcHz, diacetylhydrazineGSH, glutathioneGST, glutathione S-transferaseHepatotoxicityHz, hydrazineINA, isonicotinic acidINH, isoniazidIsoniazidMPO, myeloperoxidaseMetabolismN-Acetyltransferase 2NAD+, nicotinamide adenine dinucleotideNAT, N-acetyltransferaseP450, cytochrome P450R.M., reactive metaboliteTB, tuberculosis

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