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Lupeol and Its Role in Chronic Diseases
Fan-Shiu Tsai1, Li-Wei Lin1, Chi-Rei Wu2
1School of Chinese Medicines for Post-Baccalaureate, I-Shou University, Kaohsiung, 82445, Taiwan.
Advances in Experimental Medicine and Biology
|October 25, 2016
Summary
Lupeol, a plant-derived compound, demonstrates broad pharmacological potential, including anti-inflammatory and anti-diabetic effects. Further research suggests its promise as a lead compound for developing new therapeutic drugs.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Lupeol is a pentacyclic triterpene found in various plants.
- It exhibits diverse pharmacological activities, including antioxidant, anti-inflammatory, and anti-diabetic properties.
Purpose of the Study:
- To review the pharmacological activities and potential therapeutic applications of lupeol.
- To explore the molecular mechanisms underlying lupeol's efficacy.
Main Methods:
- Literature review of published research on lupeol.
- Analysis of preclinical (animal models) and clinical trial data.
- Examination of molecular targets and signaling pathways.
Main Results:
- Lupeol shows efficacy in various disease models, including diabetes, inflammation, and cancer.
- Clinical trials have investigated its use for canine oral malignant melanoma and human acne.
- Identified molecular targets include enzymes like α-glucosidase and signaling pathways such as NF-kB and PI3-K/Akt.
Conclusions:
- Lupeol is a multi-target agent with significant therapeutic potential.
- It may serve as a valuable lead compound for developing novel anti-inflammatory, anti-diabetic, hepatoprotective, and anticancer drugs.
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