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Related Concept Videos

Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
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Stem Cells in Functional Bladder Engineering.

Jakub Smolar1, Souzan Salemi1, Maya Horst2

  • 1Laboratory for Tissue Engineering and Stem Cell Therapy, Department of Urology, University Hospital Zurich, Zurich, Switzerland.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|October 27, 2016
PubMed
Summary
This summary is machine-generated.

Tissue engineering using stem cells offers a promising alternative to traditional enterocystoplasty for bladder reconstruction. This approach aims to overcome the complications associated with using intestinal tissue, addressing a critical need for improved bladder augmentation therapies.

Keywords:
Bladder wallStem cellsTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Urology
  • Biomaterials Science

Background:

  • Conditions like spina bifida and spinal cord injury cause severe bladder dysfunction, often requiring surgical intervention.
  • Current gold standard, enterocystoplasty, uses intestinal tissue but leads to significant long-term complications including infections, stones, and malignancies.
  • There is a critical clinical need for safer, more effective bladder augmentation strategies.

Approach:

  • This review explores recent advancements in stem cell-based tissue engineering for bladder reconstruction.
  • Focuses on bladder stem cell research, therapeutic applications, and challenges in developing functional bladder tissue.
  • Highlights stem cell-based tissue engineering (TE) as a promising future strategy for reconstructive urology.

Key Points:

  • Stem cell-based tissue engineering (TE) presents a viable alternative to enterocystoplasty for bladder augmentation.
  • Research is progressing in identifying and utilizing bladder stem cells for regenerative purposes.
  • Overcoming challenges in TE is crucial for creating functional, long-lasting bladder tissue replacements.

Conclusions:

  • Stem cell therapy holds significant promise for addressing the limitations of current bladder augmentation procedures.
  • Further research and development are necessary to translate these findings into clinical practice for patients with bladder dysfunction.
  • Developing functional engineered bladder walls is the ultimate goal for improving patient outcomes.