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The Telocyte Subtypes.

Maria-Giuliana Vannucchi1, Maria-Simonetta Faussone-Pellegrini2

  • 1Department of Experimental and Clinical Medicine, Research Unit of Histology and Embryology, University of Florence, Viale Pieraccini 6, Florence, 50134, Italy.

Advances in Experimental Medicine and Biology
|November 1, 2016
PubMed
Summary
This summary is machine-generated.

Telocytes (TCs) are unique connective tissue cells found in most organs, identifiable by transmission electron microscopy. Immunohistochemical studies reveal organ- and species-specific markers, suggesting diverse TC subtypes with distinct roles.

Keywords:
CD34ImmunohistochemistryInterstitial cellsPDGFRαTransmission electron microscope (TEM)

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Area of Science:

  • Cell Biology
  • Histology
  • Connective Tissue Research

Background:

  • Telocytes (TCs) are a distinct cell type residing in the interstitial space of connective tissue.
  • TCs possess unique ultrastructural features, making them identifiable via transmission electron microscopy (TEM).
  • Their presence has been confirmed across numerous organs, highlighting their ubiquitous nature.

Purpose of the Study:

  • To explore the characteristics and distribution of telocytes (TCs) in various organs.
  • To investigate the complexities and potential variations in telocyte (TC) immunohistochemical markers.
  • To understand the implications of these variations for telocyte (TC) function and classification.

Main Methods:

  • Transmission electron microscopy (TEM) for ultrastructural identification of telocytes (TCs).
  • Immunohistochemical analyses using markers such as CD34 and PDGFRalpha.
  • Comparative analysis of telocyte (TC) markers across different organs and species, including the human urinary bladder.

Main Results:

  • Telocytes (TCs) exhibit consistent ultrastructural features identifiable by TEM.
  • Immunohistochemical profiles of TCs vary significantly depending on the organ and species.
  • A notable exception is the human urinary bladder, where TEM-identified TCs lack double labeling for common markers (CD34/PDGFRalpha).

Conclusions:

  • Telocytes (TCs) are ubiquitous connective tissue organizers forming 3-D networks.
  • Immunohistochemical heterogeneity suggests the existence of diverse telocyte (TC) subtypes.
  • Each telocyte (TC) subtype likely performs specific, organ-/tissue-dependent physiological roles.