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Updated: Mar 12, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Leukemic Stem Cells S(p)liced Off
Margarida Ferreira-Teixeira1, Britta Will2
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abstract:
Myeloid malignancies often arise from an aging hematopoietic system and are currently incurable due to therapy-resistant, disease-reinitiating leukemic stem cells. In this issue of Cell Stem Cell, Crews et al. (2016) report RNA splice isoform signatures unique to patient-derived leukemic stem cells that constitute a therapeutic Achilles' heel of myeloid leukemia.
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