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How phosphocreatine buffers cyclic changes in ATP demand in working muscle
1Department of Mechanical Engineering, University of Rochester, NY 14627.
Advances in Experimental Medicine and Biology
|January 1, 1989
Abstract:
1. Spatial buffering is hardly necessary for maintaining ATP concentration. 2. Temporal buffering may be essential to defend concentration of products of ATP hydrolysis. ADP would vary 4-fold and AMP would vary 16-fold during a single twitch without buffering. 3. The principal function of the transphosphorylating reaction may be to buffer temporally the concentrations of controlling reactants.