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Updated: Mar 12, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Real-World Experience With Apremilast in Treating Psoriasis
Julia N Mayba1, Melinda J Gooderham2,3,4
11 University of Manitoba Faculty of Health Sciences, College of Medicine, Winnipeg, MB, Canada.
Journal of Cutaneous Medicine and Surgery
|November 16, 2016
Summary
Apremilast, an oral phosphodiesterase-4 inhibitor, effectively treated psoriasis in a real-world setting, showing significant clinical improvement with good tolerability. Nausea and vomiting were the most common side effects leading to discontinuation.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Psoriasis is a chronic inflammatory skin condition impacting quality of life.
- Existing treatments for psoriasis include topical, systemic, and biologic medications.
- Real-world data on apremilast (oral phosphodiesterase-4 inhibitor) for psoriasis are limited.
Purpose of the Study:
- To evaluate the efficacy and tolerability of apremilast in a community dermatology practice.
- To assess the real-world patient experience with apremilast for psoriasis treatment.
- To identify common side effects and reasons for treatment discontinuation.
Main Methods:
- Retrospective chart review of electronic medical records.
- Inclusion of patients prescribed apremilast for psoriasis in a community dermatology setting.
- Analysis of clinical disease severity, treatment response, and adverse events.
Main Results:
- Apremilast improved clinical disease severity in 63 out of 81 patients who took the medication.
- 37% of patients achieved a body surface area involvement of less than 1%.
- Apremilast was generally well-tolerated, with nausea and vomiting being the most frequent side effects leading to discontinuation.
Conclusions:
- Apremilast demonstrates significant clinical improvement in psoriasis patients in a real-world setting.
- The oral phosphodiesterase-4 inhibitor is a safe and well-tolerated treatment option.
- Patient experience with apremilast for psoriasis is positive, despite common gastrointestinal side effects.
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