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Genetic variants associated with primary open angle glaucoma in Indian population
Sunil Kumar1, Manzoor Ahmad Malik1, Sooraj K1
1Department of Ocular Biochemistry, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Genomics
|November 17, 2016
Summary
This study reviews glaucoma prevalence changes globally and in India since 1993. It also compiles genes linked to primary open-angle glaucoma (POAG) in the Indian population.
Area of Science:
- Ophthalmology
- Genetics
- Epidemiology
Background:
- Glaucoma is a common optic nerve disorder leading to vision loss.
- Primary open-angle glaucoma (POAG) is the most frequent subtype.
- Numerous genetic loci and genes are implicated in POAG pathogenesis, with ongoing research.
Purpose of the Study:
- To summarize global and Indian glaucoma prevalence trends from 1993 onwards.
- To compile and review genes associated with POAG in the Indian population.
- To consolidate current knowledge on POAG genetics and epidemiology.
Main Methods:
- Literature review and synthesis of epidemiological data on glaucoma prevalence.
- Compilation and analysis of genetic association studies related to POAG in India.
- Review of established and newly identified genes involved in POAG.
Main Results:
- The study details shifts in glaucoma prevalence worldwide and specifically within India.
- It presents a comprehensive list of genes studied in relation to POAG in the Indian context.
- Identifies genetic loci and specific genes contributing to POAG pathogenesis.
Conclusions:
- Glaucoma prevalence is dynamic, necessitating updated epidemiological data.
- Understanding the genetic basis of POAG in the Indian population is crucial for targeted interventions.
- Continued genetic research is vital for advancing POAG management and treatment.
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