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Updated: Mar 12, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Coronary Sinus-Based Approach to Mitral Regurgitation
Steven L Goldberg1, Christoph Hammerstingl2
1Rocky Mountain Heart & Lung, Kalispell Regional Medical Center, 350 Heritage Way, Suite 2100, Kalispell, MT 59901, USA; Cardiac Dimensions, Inc, 5540 Lake Washington Boulevard NE, Kirkland, WA 98033, USA.
Functional mitral regurgitation (FMR) worsens heart failure outcomes. The Carillon device, which cinches the mitral annulus via the coronary sinus, is being evaluated in a randomized trial for FMR treatment.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure
Background:
- Functional mitral regurgitation (FMR) significantly worsens clinical outcomes in patients with congestive heart failure.
- Current treatment strategies for FMR aim to improve mitral valve function and reduce clinical impact.
- Devices utilizing the coronary sinus-posterior mitral annulus relationship offer a novel therapeutic approach.
Purpose of the Study:
- To evaluate the therapeutic value of the Carillon device for treating functional mitral regurgitation.
- To assess the efficacy and safety of a novel mitral annulus cinching technique.
Main Methods:
- A double-blind, randomized trial is currently underway.
- The study builds upon favorable results from three prior safety and efficacy trials.
- The Carillon device leverages the coronary sinus and posterior mitral annulus for therapeutic effect.
Main Results:
- Prior safety and efficacy trials have yielded favorable results.
- European approval has been granted for the Carillon device.
- A randomized trial is ongoing to further evaluate its clinical value.
Conclusions:
- The Carillon device represents a promising therapeutic option for functional mitral regurgitation.
- Transcatheter mitral valve repair techniques are advancing treatment for heart failure patients.
- Further evaluation in randomized trials will solidify the role of this device in clinical practice.
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