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Characteristics of Lipoprotein(a)-Containing Circulating Immune Complexes as Markers of Coronary Heart Disease

E A Klesareva1, O I Afanas'eva2, V V Donskikh2

  • 1Russian Cardiology Research and Production Center, Ministry of Health of the Russian Federation, Moscow, Russia. hea@mail.ru.

Bulletin of Experimental Biology and Medicine
|December 2, 2016
PubMed

Insights

This study found that circulating immune complexes containing lipoprotein(a) (Lp(a)) and autoantibodies to Lp(a) are present in coronary heart disease (CHD) patients with high Lp(a) levels, suggesting an immune role in Lp(a)-driven atherothrombogenicity.

Area of Science:

  • Cardiovascular immunology
  • Atherosclerosis research
  • Lipoprotein metabolism

Background:

  • High levels of lipoprotein(a) (Lp(a)) are a risk factor for coronary heart disease (CHD).
  • The role of immune complexes involving Lp(a) in CHD pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the composition of circulating immune complexes (CICs) in patients with CHD and high Lp(a).
  • To determine the presence and characteristics of Lp(a)-containing CICs in relation to Lp(a) levels and autoantibodies.

Main Methods:

  • Immune complexes were precipitated from patient sera using polyethylene glycol.
  • Quantification of Lp(a), autoantibodies to Lp(a), IgG, and IgM within the isolated CICs.
  • Comparison between healthy donors and CHD patients with varying Lp(a) levels.

Main Results:

  • Circulating immune complexes containing Lp(a) were identified in CHD patients with elevated Lp(a) concentrations.
  • The presence of Lp(a), autoantibodies to Lp(a), and CICs was correlated in these patients.

Conclusions:

  • The findings suggest an immunological contribution to the atherothrombotic potential of Lp(a).
  • Immune complexes involving Lp(a) may play a significant role in the development of CHD.

Keywords:
atherosclerosisautoantibodiescirculating immune complexescoronary heart diseaselipoprotein(a)

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